Modern research and the tools available to today’s medical researchers generate large, diverse, and complex data sets. Our research communities have become a data-intense enterprise, representing everything from disease pathogenesis to information about trends, associations, and connections between points of patient data. These studies, which represent some of the work being done as part of the NIH Social, Behavioral and Economic Impacts of COVID-19 initiative, aim to produce findings and solutions from multiple data sets to better understand and address the broader effects of the epidemic.