Over the years, NIH has released policies to encourage data sharing. Our first data sharing policy in 2003 was limited to awards requesting more than $500,000 in direct costs in any year. Subsequent data sharing policies focused predominantly on genomic data sharing (Genome-Wide Association Studies Policy; Genomic Data Sharing Policy). There are clear and well-accepted advantages of data sharing including increasing sample size, facilitating reproducibility analyses, and increasing the impact of the taxpayer’s investment in data collection to advance science. These advantages are not limited to large grants or to genomic studies; they are applicable to data sharing of nearly all of the research that the NIH supports. Therefore, after considering initial input from the scientific community, the NIH this week released its Draft NIH Policy for Data Management and Sharing that is intended to encourage data sharing of all NIH-supported research.